Sharlene Washington Selected Research

Eflornithine (Ornidyl)

11/2008	Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells.
1/2008	Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
1/2008	Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
11/2007	Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
9/2007	Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells.
12/2005	Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
1/2005	Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
1/2005	Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment.
1/2004	Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
1/2003	Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice.

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Sharlene Washington Research Topics

Disease

15	Breast Neoplasms (Breast Cancer) 11/2011 - 01/2002
11	Neoplasms (Cancer) 01/2015 - 01/2002
6	Carcinogenesis 01/2015 - 03/2010
6	Neoplasm Metastasis (Metastasis) 01/2012 - 01/2003
1	Retinoblastoma (Glioblastoma, Retinal) 12/2005

Drug/Important Bio-Agent (IBA)

11	PolyaminesIBA 11/2008 - 01/2002
10	Eflornithine (Ornidyl)FDA Link 11/2008 - 01/2003
6	Fish OilsIBA 01/2015 - 03/2010
6	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 11/2008 - 01/2002
5	Tamoxifen FDA LinkGeneric 04/2014 - 03/2010
4	Hormones (Hormone)IBA 08/2011 - 12/2004
4	EnzymesIBA 11/2008 - 01/2002
4	Biological ProductsIBA 01/2008 - 01/2004
3	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 04/2014 - 03/2010
3	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 01/2012 - 03/2010
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2015 - 03/2010
2	Biomarkers (Surrogate Marker)IBA 04/2014 - 11/2011
2	Caspase 3 (Caspase-3)IBA 01/2008 - 09/2007
1	CytokinesIBA 01/2015
1	Messenger RNA (mRNA)IBA 01/2012
1	RNA (Ribonucleic Acid)IBA 01/2012
1	Dietary Fats (Dietary Fat)IBA 01/2012
1	gamma-Synuclein (Persyn)IBA 01/2012
1	Estrogens (Estrogen)FDA Link 11/2011
1	Corn Oil (Oil, Corn)IBA 08/2011
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 08/2011
1	Estrogen ReceptorsIBA 08/2011
1	Glutathione (Reduced Glutathione)IBA 03/2010
1	LigandsIBA 03/2010
1	Estrogen Receptor Modulators (Antiestrogen)IBA 03/2010
1	AntioxidantsIBA 03/2010
1	PPAR gammaIBA 03/2010
1	tyrosine receptor (receptor, tyrosine)IBA 11/2008
1	Phosphotransferases (Kinase)IBA 11/2008
1	Carrier Proteins (Binding Protein)IBA 01/2008
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2008
1	Extracellular Matrix ProteinsIBA 11/2007
1	Thrombospondin 1IBA 11/2007
1	Proteins (Proteins, Gene)FDA Link 12/2005
1	Mitogen-Activated Protein KinasesIBA 12/2005
1	OrnithineIBA 01/2005
1	Pharmaceutical PreparationsIBA 01/2005
1	PutrescineIBA 01/2005
1	Green Fluorescent ProteinsIBA 01/2005
1	SpermineIBA 12/2004
1	Adenosylmethionine DecarboxylaseIBA 12/2004
1	4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664)IBA 12/2004
1	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA 01/2004
1	Chemotactic FactorsIBA 01/2004
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2004
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2004
1	Peptides (Polypeptides)IBA 01/2004

Therapy/Procedure

3	Therapeutics 01/2008 - 01/2003
1	Treatment Delay 01/2005
1	Intravenous Injections 01/2005
1	Drug Therapy (Chemotherapy) 01/2005